Platelet-activating Factor And Related Lipid Mediators 2: Roles In Health And Disease

Comprises The Proceedings Of The Fifth International Congress Held In Berlin In September, 1995. The Volume's 62 Contributions Distill The Current State Of Knowledge On The Chemistry, Biology, Physiology, And Pathology Of Platelet-activating Factor (paf) And Reflect The Sequence Of The Main Sessions Of The Congress. Topics Include Inter Alia Paf Synthesis And Transport, Molecular Structure And Heterogeneity Of Paf-receptor, Regulation Of Gene Expression By Paf, Signal-transducing Role Of Paf And Other Phospholipids, The Role Of Paf And Paf-receptor In Infectious Diseases, Circulation, And Reproduction. Attention Is Given To Addressing The Roles And Mechanisms Of Action Of Acetylhydrolase In Human Diseases And Application Of Ether Lipids In Prevention Of Tumor Growth. The Last Chapter Describes Clinical Trials On The Application Of Paf Antagonists For The Treatment Of Asthma And Pancreatitis. 1. The Continuing Biochemical Challenge Of Paf And Closely Related Lipid Mediators / Donald J. Hanahan -- 2. Biosynthesis Of Platelet-activating Factor And Enzyme Inhibitors / Fred Snyder, Veronica Fitzgerald And Merle L. Blank -- 3. Inhibitors Of Arachidonate Metabolism And Effects On Paf Production / James D. Winkler, Chiu-mei Sung And Lisa A. Marshall [et Al.] -- 4. Production Of Platelet-activating Factor By Brain Microvascular Endothelial Cells / Kei Satoh, Masayuki Koyama And Hidemi Yoshida [et Al.] -- 5. Paf-synthesizing Enzymes In Neural Cells During Differentiation And In Gerbil Brain During Ischemia / Ermelinda Francescangeli, Loius Freysz And Gianfrancesco Goracci Edited By Santosh Nigam, Gert Kunkel, And Stephen M. Prescott. Proceedings Of The Fifth International Congress On Platelet-activating Factor And Related Lipid Mediators, Held September 12-16, 1995, In Berlin, Germany--t.p. Verso. Includes Bibliographical References And Index.