Neurodegenerative Diseases: Unifying Principles

As The Global Population Ages The Impact Of Neurodegenerative Diseases Like Alzheimer's Disease And Parkinson's Disease Are Significant Forces In Shaping Human Health And Quality Of Life In The 21st Century. Insights Into Understanding These Diseases, And Knowing How To Treat Them Are Major Frontiers Of Scientific Research. Neurodegenerative Diseases: Unifying Principles Is The Result Of A Conceptual Revolution Over The Last Decade In Our Understanding Of Neurodegenerative Diseases As Sharing Unifying Features. There Is An Increasing Appreciation Of The Common Biological And Pathological Features Across Seemingly Varied Neurodegenerative Diseases That Entail Protein Misfolding Dysfunction And Its Consequences Over Time. Providing An Overview Of This Conceptual Change Is The Main Theme For The Book. Conventional Approach Emphasize The Differences Among Neurodegenerative Disorders, Here Drs. Cummings And Pillai Compile The Increasingly Compelling Evidence That These Disorders Share Many Features And That Insights In One May Be Rapidly Translated Into Advances In Another. The Goal Is To Accelerate Understanding By Showing Linkages Among Biological, Pathological, Can Clinical Aspects Of This Class Of Diseases. This Collection Of 19, Inter-related Chapters, Articulates And Broadens Our View Of The Unifying Features That Initiate And Drive Disease Progression Across A Variety Of Neurodegenerative Diseases Over Time. This Book Will Serve As An Outstanding Sourcebook Of Insights From Experts That Have Played Key Roles In This Story. Presents A Thorough Examination Of The Unifying Principles From The Subcellular To The Systems And Clinical Levels; Identifies Common Themes Among Molecular Biology, Genetics, Physiology, Pathology, Biomarkers, Behavior, And Treatment Strategies That Are Shared Between Neurodegenerative Diseases; Enables Better Care Of Patients And Help Build Collaboration Across Researchers In Multiple Specializations That Could Help Advance Future Insights And Facilitate Novel Therapies And Enhancing Basic Scientific Understanding Of These Diseases To A New Generation. Neurodegenerative Diseases : Evolving Unifying Principles / Jeffrey Cummings And Jagan Pillai -- Neurodegenerative Diseases As Protein Misfolding Disorders / Tomohiro Nakamura And Stuart A. Lipton -- Calcium Hypothesis On Neurodegeneration : The Case Of Ad And Hd / Daniel A. Ryskamp, Elena Popugaeva, And Ilya Bezprozvanny -- Inflammation In Neurodegenerative Diseases / Bruce Lamb -- Prion Paradigm Of Human Neurodegenerative Diseases Caused By Protein Misfolding / Jiri Safar -- Neuropsychiatric Features Across Neurodegenerative Diseases / Claudia R. Padilla, Mario F. Mendez -- Brain Circuits : Pathway For Ndd / William Seeley. Fluid Biomarkers Indicative Of Neurodegenerative Diseases / Henrik Zetterberg And Jonathan M. Schott -- Predementia Disorders : Neurodegenerative Diseases Predecessor States As Unifying Clinical Features / Jagan Pillai -- Genetics Of Neurodegenerative Diseases : Sporadic And Autosomal Dominant Forms / Lars Bertram And Max Planck -- An Epigenetics Perspective On Diseases Of The Central Nervous System / Diego Mastroeni -- Mitochondrial Changes And Bioenergetics In Neurodegenerative Diseases / Andrew B. Knot And Ella Bossy-wetzel -- Systems Biology In Neurodegenerative Diseases / Lawrence Rajendran -- Cell Culture And Ips Cells And Neurodegenerative Diseases / Roxana Nat. Animal Models Of Neurodegenerative Diseases / David Baglietto-vargas, Ager Rr, Medeiros R, And Frank M. Laferla -- Metal-protein Attenuating Compounds In Neurodegenerative Diseases / Peng Lei, Scott Ayton, And Ashley I. Bush -- Disease Modifying Therapies In Neurodegenerative Disorders / Janelle Drouin-ouellet And Roger A. Barker -- Immunotherapy For Neurodegenerative Disorders / David Morgan -- Clinical Trials And Drug Development In Neurodegenerative Diseases : Unifying Principles / Jeffrey Cummings And Kate Zhong -- Conclusions On Neurodegenerative Disorders : Unifying Principles / Jagan Pillai And Jeffrey Cummings. Edited By Jeffrey L. Cummings, Jagan A. Pillai. Includes Bibliographical References And Index.